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40 Studies with peptide and protein model systems indicate that replacing Gly with L-Ala stabilizes a right-handed -helical conformation by up to 1 kcal/mol, 4143 while replacing Gly with D-Ala destabilizes the -helical conformation by up to 0.5 kcal/mol

Adherence to therapy with respect to the safety profile is also to be considered

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These effects can drive treatment discontinuation, particularly during an increase in dosage

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